Abstract
Objective. To assess the effectiveness of tranexamic acid in the surgical correction of idiopathic scoliosis. Material and Methods . The study included a retrospective analysis of intraoperative and postoperative blood loss during surgical correction of idiopathic scoliosis in 198 patients. In 70 patients, the operation was performed without administration of tranexamic acid. In 58 patients, tranexamic acid was administered 15 minutes before the skin incision at a dose of 10 mg/kg, and continued uninterruptedly at a dose of 1 mg/kg/h. In 70 patients, tranexamic acid was administered continuously during the operation at a dose of 10 mg/kg. Patients underwent surgery in a prone position with full decompression of the anterior abdominal wall. Results . The registered intraoperative blood loss in most cases corresponded to Class I (no more than 750 ml or 15 % of blood volume) and Class II (no more than 750-1500 ml or 15-30 % of blood volume) according to the WHO classification of severity. The volume of intraoperative blood loss was not statistically different between groups. Significant differences were detected only in assessing parameters of postoperative blood loss. Conclusion . The use of tranexamic acid in surgical correction of scoliosis does not affect the bleeding index of tissues at the surgical site and the total intraoperative blood loss. Using tranexamic acid in spine surgery is a technological procedure allowing for significant reduction in postoperative blood loss.
Highlights
The registered intraoperative blood loss in most cases corresponded to Class I and Class II according to the WHO classification of severity
Using tranexamic acid in spine surgery is a technological procedure allowing for significant reduction in postoperative blood loss
Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology. 2006;105:1034–1046
Summary
Анализ эффективности применения транексамовой кислоты при хирургической коррекции идиопатического сколиоза. Проведен ретроспективный анализ интраоперационной и послеоперационной кровопотери в процессе хирургической коррекции идиопатического сколиоза у 198 пациентов. Интраоперационная укладка – положение на животе с обеспечением полной декомпрессии передней брюшной стенки. Зарегистрированная интраоперационная кровопотеря в большинстве случаев соответствовала I (15–30 % ОЦК) степени тяжести по классификации ВОЗ. При этом объем интраоперационной кровопотери в группах статистически не различался. Достоверные различия были установлены только при оценке показателей послеоперационной кровопотери. Применение транексамовой кислоты при хирургической коррекции сколиоза не влияет на степень кровоточивости тканей в зоне операции и итоговую величину интраоперационной кровопотери. Использование транексамовой кислоты при операциях на позвоночнике является технологическим приемом, позволяющим значимо уменьшить величину послеоперационной кровопотери. Ключевые слова: идиопатический сколиоз, кровопотеря, транексамовая кислота.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
