Use of synthetic estrogenic substance chlorotrianisene (TACE) in treatment of acne.

Abstract

IN AUGUST, 1952, an editorial in The Journal of the American Medical Association was devoted to a new long-acting estrogen, TACE. Because of its importance, major portions of the editorial are quoted herewith. The discovery that the synthetic compound diethylstilbestrol possessed high estrogenic activity when administered orally prompted a search for related compounds with a more prolonged activity. In 1942, Robson and his associates reported that the triphenyl ethylene derivative diethoxy-triphenyl bromoethylene ( αα -di[-p-ethoxyphenyl] β -phenyl bromoethylene), or D. B. E., showed a markedly prolonged estrogenic action in mice subjected to ovariectomy when given in doses somewhat greater than those producing a threshold response. The English investigators showed this prolonged effect was due to the fact that, on introduction into the body, D. B. E. in contrast to the estrogenic substances then available was not immediately destroyed or excreted in the urine but was stored in a number of