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Abstract
Urothelial Carcinoma of the Bladder Metastatic to Bone Marrow Presenting as Isolated Thrombocytopenia
Highlights
In the event of a similar future presentation of isolated thrombocytopenia in the setting of invasive urothelial carcinoma (UC), the clinician should consider a bone marrow biopsy, in addition to the standard workup for metastatic bony involvement, prior to proceeding with any surgical intervention
Transitional cell carcinoma of the bladder frequently metastasizes to the lymph nodes (51–88%), liver (13–51%), lungs (36–40%), bone (22–37%), adrenal glands (6–21%), and rarely soft tissue and brain (2– 6%)[2]
Once commonly used for staging in patients with known transitional cell carcinoma, are no longer recommended for asymptomatic patients as they are usually unable to identify patients with tumor stage T2 or greater who will not be cured by total cystectomy[3]
Summary
In the event of a similar future presentation of isolated thrombocytopenia in the setting of invasive UC, the clinician should consider a bone marrow biopsy, in addition to the standard workup for metastatic bony involvement, prior to proceeding with any surgical intervention. This case report describes the case of a 53-year-old male with muscle-invasive transitional cell carcinoma of the bladder treated with cystoprostatectomy. Standard workup for metastatic bony involvement, which included history, physical, chest X-ray, and whole body CT, was negative.
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