Abstract
Estrone (E1), estradiol 17β (E2), estriol (E3) and 17-ketosteroid (17-KS) excretion were studied in 7 young men before and during human chorionic gonadotropin (HCG) stimulation, and the findings were compared with those from 16 old men and 5 hypogonadal men. One patient was studied again after castration. Secondary sexual development correlated: (a) with 17-KS excretion, but better with that of E1 and the total of the 3 estrogens (ET); (b) well with the HCG-stimulated increments of each of the 3 estrogens, especially that of E1 The presence or the absence of old age correlated: (a) well with E1 and 17-KS excretion and somewhat less well with E2 and ET excretion; (b) with the HCG-stimulated 17-KS and estrogen increments, especially that of E1. The E1 response to HCG stimulation is recommended as a test of testicular endocrine function. The mean E2/E1 ratio was lower in young healthy men than in old or hypogonadal men —with or without HCG stimulation. The mean E1/ET ratio was higher in young than in old men, the reverse being true for the E3/ET ratio. The mean HCG-stimulated level of E3 excretion was lower in men with prostatic carcinoma than in men of similar age with benign prostatic hyperplasia (BPH).
Published Version
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