Update in Cystic Fibrosis 2005

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Cystic fibrosis (CF) is a complex, hereditary disease involving several organ systems (1). CF is caused by mutations in the gene that codes for the CF transmembrane conductance regulator (CFTR), a membrane glycoprotein that contributes to regulation of ion flux at certain epithelial surfaces. Lung disease results in most of the morbidity and mortality in CF. Advances in CF over the past several decades have recently been reviewed with an emphasis on the development and importance of CF care centers and on opportunities for new treatments (2). The many threads of CF research in 2005 can be appreciated in Figure 1, showing the general headings (1) Molecular and Cellular Biology and Genetics, (2) Pathophysiology, and (3) Clinical Care and Treatment, along with several subheadings. This brief update reviews representative, significant articles in 2005. Figure 1. Research in cystic fibrosis (CF) in 2005. Research in CF is listed by major headings: (1) -Molecular and Cellular Biology and Genetics, (2) Pathophysiology, and (3) Clinical Care and Treatment. Important subheadings are listed under each major heading. ...