Chaperoning the maturation of the cystic fibrosis transmembrane conductance regulator.

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the endoplasmic reticulum (ER) serves as a way station during the biogenesis of nearly every integral membrane and secreted protein synthesized in eukaryotic cells. As such, its primary role is to facilitate the folding of nascent polypeptides. Thus plentiful among the ER resident proteins are 1 )