Unveiling the therapeutic mechanism of drug-loaded nanoparticles for cancer treatment: An in-depth exploration of how these nanoparticles respond to the tumor microenvironment

Abstract

The development of a drug carrier system that can specifically release drugs at tumor sites is crucial for improving the anti-tumor effect of drugs and reducing their toxic and side effects. To achieve this, researchers have studied the targets of the tumor microenvironment and different targeting strategies for nanoparticle drug delivery systems. In this study, a new multifunctional nanoparticle drug delivery system was developed by synthesizing folate-modified chitosan micelle material FA-CHI-DMA-LA. The use of nano-drug carriers can prolong the circulation time of drugs in vivo, leading to increased drug enrichment in tumor areas through passive tumor targeted drug delivery. This is achieved by the high permeability and long retention effect of solid tumors. Attaching anticancer drugs to nanoparticles allows for the control of their distribution in tissues and cells, leading to increased anticancer efficacy and reduced toxic and side effects. The developed nanoparticle drug carrier in this study has high drug loading capacity and can achieve targeted drug delivery. Positioning the anticancer drugs in tumor cells through indirect or direct action can enhance the efficacy of the drugs and minimize adverse reactions.