Abstract
The goal of this study was to create the ideal transfersome formulation for the treatment of nail infections utilizing different ratios of Phospholipon® 90 G and Tween® 80. (ranging from 95-75:5-25 percent weight-to-weight). In the study, the transfersomes' size, shape, zeta potential, polydispersity index, in vitro skin penetrability, entrapment effectiveness, and in vivo skin irritation were all evaluated. According to the findings, the transfersomes exhibited an entrapment effectiveness ranging from 40.37 to 84.61 percent and had a negatively charged, spherical unilamellar shape with diameters ranging from 132.97 nm to 553.06 nm. The transdermal flux index of the gel formulation over the rat skin was 0.0240.002 mg/cm2/h, demonstrating efficient drug transportation. The transfersomes were also shown to be non-irritating to the skin in in vivo skin irritation experiments. The research concluded that the use of transfersomes loaded with Tween® 80 can enhance the transdermal delivery of Efinaconazole. These findings suggest that the transfersomes formulation has the potential to become a promising carrier for Efinaconazole, which could be scaled up using the factors mentioned. Therefore, this study provides evidence of the efficacy of Efinaconazole in treating nail infections and the potential for the formulation to be developed into a successful treatment option.  
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call