Abstract
Heart Failure is a worldwide burden. The prevalence, incidence, mortality and morbidity rates reported show geographic variations, depending on the different aetiologies and clinical characteristics observed among patients with this complex syndrome. In this review we focus on the Afro Caribbean population with Heart Failure providing data review about the Heart Failure etiology based in previous Clinical Trials In addition we provide suggestions based in these Trials and our recent observational clinical studies that might be useful to improve our current Heart Failure Guideline-Directed Medical Therapy . Finally we highlight the need for more regional research.
Highlights
There is no doubt that Heart Failure is a complex syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood [1], Heart Failure is a disease in which there are striking population differences in almost every aspect of the disease
The majority of the data on Heart Failure in African descendant has been done in African American population and that research should be validated in the Caribbean Region
The 2017 ACC/AHA Guidelines Update [24] has recommended for patients with chronic HFrEF, to reduce morbidity and mortality the Angiotens in Receptor Neprilysin Inhibitor (ARNI) in conjunction with Beta Blocker (Class I, LOE B-R) and for patients with chronic symptomatic HFrEF, NYHA class II-III, who tolerate an ACE Inhibitor or ARB: the ARNI, to replace an ACE Inhibitor or ARB (Class I, LOE B-R) More understanding about the population of African Americans has been mentioned in the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure with Reduced Ejection Fraction [25] which has stated that in African Americans Sacubitril/Valsartan and Ivabradine were tested in populations with few African Americans receiving HYD/ ISDN
Summary
Understanding the Demographic and Clinical Characteristics of Heart Failure to Improve.
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