Abstract

Inwardly rectifying potassium (Kir) channels play a critical role in stabilizing the membrane potential, thus controlling numerous physiological phenomena in various tissues. Channel conductance can be activated by cytoplasmic modulators that open the channel at the ‘helix bundle crossing’ (HBC), formed by the coming together of the M2 helix from each of the four subunits, at the cytoplasmic end of the transmembrane pore.

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