UiO-66 nanoparticles as a drug delivery system: A comprehensive review

Abstract

Metal-organic frameworks (MOFs) are coordination polymers that are synthesized by bonding functional organic ligands with metal ion/cluster nodes. “Cooperation polymers” is a term used to describe a type of metal-organic framework (MOF) that is synthesized by coordination bonding between functional organic ligands and metal ion/cluster nodes. MOFs are a fascinating and practical family of materials that have seen a significant increase in research interest over the past several decades. They are used for biomedical applications and are capable of extending in one, two or three dimensions [1]. The classic metal-organic framework (MOF), UiO-66, has a large surface area and excellent thermal consistency. It is determined that the cuboctahedral structure of the metal oxide node, which offers 12 extension sites for coordination with a 1,4-benzene dicarboxylic acid (BDC), accounts for the stability. The exceptional tenability and utility of UiO-66, primarily due to the defect management of defective, missing clusters and linkers, have made it popular in nanoscience. This material is very compatible due to these properties and is used in a wide range of fields [2]. It has been shown that UiO-66 MOFs are an effective drug delivery vehicle for chemotherapeutic drugs and release [3]. A historical overview of UiO-66 is presented in this report, along with a discussion of the objective breakthroughs that revolutionized Zr-based MOF synthesis's current and future research on defect control, crystallization in water, and tradeoffs between functionality and consistency. Different drug delivery systems like PH-responsive Drug Delivery Systems (DDSs), Magnetic Drug Delivery (MDD), and other types of drug delivery were described.