Abstract
Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Purification of the extract yielded two new macrolides 2 and 3 along with known candidaspongiolide (1). The structures for compounds 2 and 3 were elucidated by spectral analysis (1H, 13C, COSY, HMQC, HMBC) and by comparison of their NMR data with those of 1. Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC50 4.7 and 19 ng/mL) than that (IC50 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.
Highlights
A group of sedentary organisms, cannot move and escape from predators. Most sponges are filter feeders pumping water to its body to obtain foods and oxygen and to expel wastes and may be threatened by microorganisms during filtering seawater rich in bacteria and fungi [1, 2]
Sponges, a group of sedentary organisms, cannot move and escape from predators
Marine sponges have been recognized as potentially rich sources of various bioactive molecules
Summary
A group of sedentary organisms, cannot move and escape from predators. Most sponges are filter feeders pumping water to its body to obtain foods and oxygen and to expel wastes and may be threatened by microorganisms during filtering seawater rich in bacteria and fungi [1, 2]. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC50 4.7 and 19 ng/mL) than that (IC50 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.
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