Formulation development and optimization of fast dissolving tablets of aceclofenac using natural superdisintegrant.

Lovleen Kaur,Rajni Bala,Neha Kanojia,Gitika Arora Dhingra,Manju Nagpal

doi:10.1155/2014/242504

Lovleen Kaur, Rajni Bala + Show 3 more

Open Access

https://doi.org/10.1155/2014/242504

Copy DOI

Journal: ISRN pharmaceutics	Publication Date: May 8, 2014
Citations: 11	License type: CC BY 3.0

Affiliation: Chitkara University, Sterling Hospitals

Abstract

The current research work involves preparation of fast dissolving tablets of Aceclofenac by direct compression method using different concentrations of Lepidium sativum mucilage as natural superdisintegrant. A two-factor three-level (32) factorial design is being used to optimize the formulation. Nine formulation batches (D1–D9) were prepared accordingly. Two factors as independent variables (X 1-amount of β-cyclodextrin and X 2-amount of Lepidium sativum mucilage) were taken with three levels (+1, 0, −1). The levels of two factors were selected on the basis of preliminary experiments conducted and their effect on three dependent variables (disintegration time, wetting time, and in vitro drug release) was studied along with their % prediction error. All the active blends were evaluated for postcompression parameters (angle of repose, Carr's index, Hausner ratio, etc.) and the tablets were evaluated for postcompression parameters (weight variation, hardness, and friability, wetting time, disintegration time, water absorption ratio, and in vitro drug release studies). The optimum batch was further used for SEM and stability studies. Formulation D5 was selected by the Design-Expert software which exhibited DT (15.5 sec), WT (18.94 sec), and in vitro drug release (100%) within 15 minutes.

Highlights

Oral route of drug administration has wide acceptance up to 50–60% of total people experience inconvenience in swallowing conventional dosage forms such as tablets when water is not available, in the case of motion sickness and sudden episodes of coughing during the common cold, allergic conditions, and bronchitis
That is, amount of β-cyclodextrin and amount of Lepidium sativum mucilage at three levels were selected on the basis of preliminary studies
Addition of superdisintegrant Lepidium sativum mucilage leads to significant effect on disintegration characteristics as well as drug release

Summary

Introduction

Oral route of drug administration has wide acceptance up to 50–60% of total people experience inconvenience in swallowing conventional dosage forms such as tablets when water is not available, in the case of motion sickness (kinetosis) and sudden episodes of coughing during the common cold, allergic conditions, and bronchitis. For these reasons, tablets that can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. The increasing popularity of orally disintegrating dosage forms is in part owing to various factors such as fast disintegration, good mouth feel, easy to handle, easy to swallow, and effective taste [3, 4]

Methods

Results

Conclusion