Abstract
Designing chiral materials to manipulate the biological activities of cells has been an important area not only in chemistry and material science, but also in cell biology and biomedicine. Here, we introduce monolayer plasmonic chiral Au nanoparticle (NP) films modified with l- or d-penicillamine (Pen) to be developed for cell growth, differentiation, and retrieval. The monolayer films display high chiroptical activity, with circular dichroism values of 3.5 mdeg at 550 nm and 26.8 mdeg at 775 nm. The l-Pen-NP films accelerate cell proliferation, whereas the d-Pen-NP films have the opposite effect. Remote irradiation with light is chosen to noninvasively collect the cells. The results demonstrate that left circularly polarized light improves the efficiency of cell detachment up to 91.2% for l-Pen-NP films. These findings will facilitate the development of cell culture in biomedical application and help to understand natural homochirality.
Highlights
Designing chiral materials to manipulate the biological activities of cells has been an important area in chemistry and material science, and in cell biology and biomedicine
After the addition of retinoic acid (RA) as the inducer, the stretched cells differentiated into bipolar neurons, whereas the round cells became multipolar neurons
The distinct dihedral angle between the constituent NPs contributes to the generation of the circular dichroism (CD) signal
Summary
Designing chiral materials to manipulate the biological activities of cells has been an important area in chemistry and material science, and in cell biology and biomedicine. The use of monolayer NPs instead of simple substrate surfaces allows much higher functional group densities, providing larger numbers of chiral contact points between the cells and the ECM. We designed monolayer chiral Au NP films to promote in cell adhesion, growth, differentiation, and to be removed without damage.
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