Abstract
Colon cancer, with its alarmingly high prevalence and mortality rates, remains a formidable challenge in the realm of oncology. In pursuit of innovative strategies for precise diagnosis and effective treatment, we have developed a groundbreaking tumor microenvironment responsive biodegradable virus-like hollowed mesoporous Co3O4 based nanoreactor. This nanoagent leverages the exceptional Fenton-like activity of Co3O4 and the unique nanostructure integrates ICG dye loading with RGD peptide surface modification. Our nanoreactor emerges as a dual-functional tool: a precise tumor accumulation with real time bioimaging ability and a potent phototheranostic agent with a remarkable photo-heat conversion efficiency under 808 nm laser irradiation. Critically, the induced hyperthermia synergistically enhances reactive oxygen species (ROS) generation through Co ion catalysis of H2O2 in tumor cells, further strengthen the antitumor efficacy. Both in vitro and in vivo studies demonstrate the remarkable ability of our Co-based nanocomposite to suppress tumor growth when coupled with 808 nm laser illumination. In essence, this work underscores the immense potential of biodegradable Co3O4-based mesoporous nanoreactor as a versatile agent for precise and effective photothermal-enhanced ROS storm for colon tumor inhibition.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call