Abstract
Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors. Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS). A comprehensive, computerized literature search was undertaken by using PubMed, EMBASE, Cochrane Library, and Web of Science (up to October 10, 2017). Strength of association between 3 lncRNAs and cancer prognosis was assessed by computing the hazard ratios (HR) with its corresponding 95% confidence interval (CI). According to the inclusion and exclusion criteria, respectively, 10, 9, and 7 studies of 3 lncRNAs were included in this meta-analysis. In the current meta-analysis, it could be concluded that the expression of these 3 lncRNAs in tumor tissues is not a direct evidence of LNM. In general, there was a significant negative correlation between TUG1 levels and OS time (pooled HR 1.54, 95% CI 1.06-2.24), SPRY4-IT1 levels and OS time (pooled HR 2.12, 95% CI 1.58-2.86) and HULC levels and OS time (pooled HR 2.10, 95% CI 1.18-3.73). It could be revealed from the result that high level expression of these 3 lncRNAs might be correlated with a bad prognosis. In conclusion, the current meta-analysis demonstrated that TUG1, SPRY4-IT1, and HULC might serve as a moderate predictor of survival in human cancer.
Highlights
Cancer has been a serious public health problem world widely since the beginning of the 20th century, the overall incidence and mortality rate are on the rise.[1]
The more we study the biology of cancer, the more things should be updated, like staging standard and diagnostic methods of cancer
Inclusion criteria of the studies are as follows: Articles associating with these 3 well-known long noncoding RNAs (lncRNAs) (TUG1, SPRY4-IT1, and Hepatocellular carcinoma upregulated long noncoding RNA (HULC)) expression and prognosis of the patients should be investigated
Summary
Cancer has been a serious public health problem world widely since the beginning of the 20th century, the overall incidence and mortality rate are on the rise.[1]. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors
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