Abstract
Background: Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated correlated with clinical outcomes in various cancers. However, the results from each study are insufficient and not completely consistent. Therefore, we perform a systematic meta-analysis to evaluate the value for a feasible biomarker for metastasis and prognosis of cancer. Methods: Relevant English literatures were searched in PubMed, Cochrane Library, Web of science, Embase databases and Chinese literatures were searched in Chinese National Knowledge Infrastructure Wanfang from inception up to 17 April 2018. The pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) using random/fixed-effect were used to identify the relationship between UCA1 and lymph node metastasis (LNM) or overall survival (OS) of cancer patients. Subgroup analysis and sensitivity analysis were performed. The current meta-analysis was performed using Review Manager 5.3 and Stata 12.0 software. Results: A total of 3411 patients from 38 studies were finally included. Patients who with high UCA1 expression suffered from an increased risk of LNM (OR = 2.50; 95% CI: 1.93–3.25). UCA1 was also significantly associated with OS (HR = 2.05; 95% CI: 1.77–2.38). Subgroup analyses across several different variables also showed the similar results in LNM and OS of cancer patients. Conclusion: High expression of UCA1 was linked with poor clinical outcome. UCA1 can serve as a potential molecular marker for metastasis and prognosis in different types of cancers.
Highlights
Received: 21 June 2018Revised: 13 January 2019Accepted: 18 March 2019Accepted Manuscript Online: Version of Record published: Cancer is a major global public health problem that seriously threatens human health
We searched the electronic databases PubMed, Cochrane Library, Web of science, Embase databases, Chinese National Knowledge Infrastructure (CNKI) and Wanfang, by using ‘Urothelial carcinoma associated 1 (UCA1) or urothelial carcinoma associated 1’ as the keywords, in order to obtain potential articles referenced in the publications
We found a significantly positive correlation between UCA1 expression and lymph node metastasis (LNM) when grouped by different cut-off value [By median (OR = 2.48, 95% confidence interval (CI): 1.63–3.78, P
Summary
Received: 21 June 2018Revised: 13 January 2019Accepted: 18 March 2019Accepted Manuscript Online: Version of Record published: Cancer is a major global public health problem that seriously threatens human health. According to GLOBCAN 2012, there were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide [1]. In the United States, cancer is the second leading cause of death with an estimated 1,685,210 new cases and 595,690 deaths cancer in 2016 [2]. In China, cancer has been the leading cause of death with an estimated 4,292,000 new cases and 2,814,000 death cases in 2015 [3]. Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated correlated with clinical outcomes in various cancers.
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