Abstract
Procedure of tritium labeling vancomycin using tritium thermal activation method has been developed. The influence of target mass on the specific and total radioactivity was revealed. [3H]vancomycin was used for studying its equilibrium adsorption on nanodiamonds as well as its number that tightly bonded with surface and didn’t remove with water. It was found that adsorption from aqueous solution results in tightly bonded vancomycin with nanodiamonds that didn’t removed with water. Application of 0.028 M phosphate buffer (pH 6.7 and 2.7) leads to the equilibrium adsorption growth as much as one and a half times, while vancomycin number in the adsorption complex with nanodiamonds after washing with water was significantly reduced. Such behavior of vancomycin is due to the presence of phosphate-ions that contribute to vancomycin adsorption, but are removed during washing with water. Molecular mechanics simulation allows us to suggest the formation of multiple hydrogen bonds for formation of a durable adsorption complex of vancomycin with nanodiamonds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
