Abstract
Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes
Highlights
We investigate whether cyclopentadienyl–IrIII complexes can use NADH as a hydride source for the reduction of quinones, mimicking the action of reductases
Dione) and the related duroquinone as substrates (Scheme 2), because vitamin K is required for the synthesis of certain proteins that are involved in blood coagulation and metabolic pathways in bones and other tissues,[9] and may play an important role in the treatment of cancer, Alzheimers and other diseases.[10]
Addition of menadione (1 mm) to a solution containing NADH (0.5 mm) and complex 1 (160 mm) in phosphate buffer resulted in an EPR spectrum that is consistent with the formation of the menadione semiquinone radical anion (MCÀ; Figure 2 a), Figure 3
Summary
Various molar excesses of menadione and NADH were added to a solution of complex 1 in phosphate buffer (pH 7.2; entries 1–4 in Figure 3) and EPR spectra were recorded. Addition of menadione (1 mm) to a solution containing NADH (0.5 mm) and complex 1 (160 mm) in phosphate buffer (pH 7.2) resulted in an EPR spectrum that is consistent with the formation of the menadione semiquinone radical anion (MCÀ; Figure 2 a), Figure 3. Reduction of menadione (VK3, entries 1–4) and duroquinone (Duro, entries 5 and 6) by NADH catalyzed by complex 1 (80 mm).
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