De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex

Yao Zhao,Fuyi Wang,Peter J Sadler,Jennifer S Butler,Nicola J Farrer,Abraha Habtemariam,Ruth J Mcquitty,Huilin Li

doi:10.1002/ange.201307505

Abstract

De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex

Highlights

The photoreaction of 1 with 5’-guanosine monophosphate (5’-GMP) upon irradiation with blue light with a wavelength of 450 nm for 1 h gave (SP-4-2)
A similar result has been reported for 1 under slightly different conditions, and for related compounds.[2a,4,5] when the reaction mixture was irradiated at 420 nm for 30 min, two new photoproducts, 1 c and 1 e, were observed by HPLC (Figure 1 B)
1 c, 1 d, and 1 e are all produced by the photoreaction of 1

Summary

Introduction

The photoreaction of 1 with 5’-GMP upon irradiation with blue light with a wavelength of 450 nm for 1 h gave (SP-4-2)-. When the sample was irradiated with UVA (365 nm) for 15 min, one more species, 1 d, was found (Figure 1 C). A control experiment with 5’-GMP in the absence of 1 and UVA irradiation for 15 min showed no reaction (Figure 1 D), suggesting that 5’-GMP is stable under these conditions.

Results

Conclusion