Treatment of uric acid nephropathy with integrated traditional Chinese and western medicine

Abstract

With the development of economy and society, and the improvement of people′s living standard, the prevalence of hyperuricemia increases year by year in China, which can cause multiple organ damage. Uric acid nephropathy is a disease due to deposit of urate crystals in the kidney. At present, integrated traditional Chinese medicine and western medicine have been used in the treatment of uric acid nephropathy. In western medicine, hyperuricemia can be ameliorated by inhibiting uric acid synthesis, promoting excretion of uric acid, and suppressing inflammation, and so on. Uricase is a new class of drugs to reduce uric acid in recent years, including rasburicase and PEG-uricase. Single agents of traditional Chinese medicine, such as iridiod glycosides from paederia scandens, ethanol extract of rhizoma smilasic chinae, quercetin, and rutin, have positive roles in relieving hyperuricemia and protecting kidney. Compounds of traditional Chinese medicine, including Ermiao pill, Simiao decoction, and Siwu decoction combined with Ermiao powder can inhibit the hyperuricemia so as to improve renal function. Therefore, integrated traditional Chinese medicine and western medicine are important in the treatment of uric acid nephropathy. Key words: Hyperuricemia; Uric acid nephropathy; Integrated traditional Chinese and western medicine; Treatment