Efficacy analysis of combination of traditional Chinese and Western medicine in the treatment of senile vasovagal syncope

Abstract

Objective To explore the curative effect of combination of traditional Chinese and western medicine in the treatment of senile vasovagal syncope. Methods Eighty one elderly patients with vasovagal syncope outpatients and inpatients who were admitted from January 2016 to September 2017 in Xixi Hospital of Hangzhou were included. Among them, 38 were Western medicine group (metoprolol sustained-release tablets + tilt training), and 43 were combination of traditional Chinese and Western medicine group (radix bupleuri liver scattered flavored party + Metoprolol sustained-release tablets + tilt training). Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), depression and anxiety scores were observed before and after treatment in both groups, as well as tilt test after treatment and clinical efficacy. The patients were followed up by telephone for half a year after treatment and the recurrence was recorded. Results Heart rate, SBP, DBP and depression anxiety score were significantly reduced in both Western medicine group and combination of traditional Chinese and western medicine group after treatment, and the differences were statistically significant (t=3.55, 18.68, 13.57, 18.68, 7.74, 19.83, 10.08, 19.83; P<0.05 or P<0.01). Heart rate, SBP, DBP and depression anxiety scores of patients after treatment in the combination of traditional Chinese and western medicine group were significantly lower than those in the western medicine group, with statistically significant differences (t=4.17, 1.77, 2.89, 6.79; all P<0.05).There were 19 effective cases in the western medicine group (76.32%, 10 cases cured, 19 cases effective), and 36 effective cases in the combination of traditional Chinese and western medicine group (93.02%, 17 cases cured, 19 cases effective). The difference was statistically significant (χ2=4.462, P<0.05). Twenty-nine patients with positive tilt test and 6 patients with relapse within 6 months after treatment were in Western medicine group. Twenty-two cases with positive tilt test and 1 case with recurrence within six months after treatment were in combination of traditional Chinese medicine and Western medicine group. The differences were statistically significant (χ2=2.147, 3.083; P<0.05). Conclusion Metoprolol sustained-release tablets + tilt training are effective in the treatment of senile vasovagal syncope. Western medicine combined radix bupleuri liver flavored party is better, with improved the patient's heart rate, blood pressure levels and depression anxiety symptoms, reducing the patients with recent recurrent syncope. Key words: Chaihu liver dispersing flavor side; Metopolol sustained-release tablet; Aged; Tilt-table test; Syncope, vasovagal