Meta analysis of clinical research on the treatment of epidemic keratoconjunctivitis with combination of Chinese and western medicine

Abstract

Objective System evaluation about the clinical efficacyof combining traditional Chinese and western medicine for epidemic keratoconjunctivitispublished at home and abroad by the method of Meta analysis, and provide reference for clinicaltreatment of EKC. Methods Through the collection of PubMed, MEDLINE, China retrieval CNKI, Wanfang database, VIP database and China biomedical literature database of Chinese medicine combined with western medicine in the treatment of EKC related Chinese and English literature. According to the inclusion and exclusion criteria, the literature was extracted, and the data of the study were extracted. The combination of Chinese medicine and Western medicine was used as the treatment group, and Western medicine treatment as the control group. According to the requirement of the Meta analysis to evaluate the quality of the literature retrieved, and use the RevMan5.3 for researching according to the Meta analysis, evaluation of the clinical curative effect of EKC. The revised Jadad quality scoring method was used to evaluate the included literature. The chi square test was used to test the heterogeneity of the study. If the P>0.05 indicated the homogeneity was better, the fixed effect model was used; otherwise, the random effect model was used to calculate the combined effect. The total effective rate was expressed by relative risk (OR) and 95% confidence interval. Results 7 trials including 520 patients were included. There were 553 eyes in the treatment group and 469 eyes in the control group. 7 articles are the combination of traditional Chinese and Western medicine treatment group and the control group, the total effective rate of treating EKC, after heterogeneity test, the difference was statistically significant (I2=15%, P>0.05), suggesting good homogeneity, so we use the fixed effect model of Meta analysis. The results showed that the difference between the two groups was statistically significant(OR=9.00, 95% confidence interval: 4.53~17.89, Z=6.27, P<0.05). It shows that the combination of traditional Chinese medicine and Western medicine is better than western medicine in the treatment of traditional Chinese medicine and Western medicine. Conclusion The overall effective rate of combining traditional Chinese and western medicine for EKC is significantly superior to control group. Key words: Epidemic keratoconjunctivitis; Combination of Chinese traditional and Western medicine; Meta-analysis