Abstract
Menorrhagia during the reproductive years may be caused by an imbalance in the metabolism of local endometrial prostaglandins [1]. A micronized purified flavonoid fraction (MPFF; Daflon 500, Serdia, India) containing 90% of diosmin and 10% of flavonoids expressed as hesperidin has been shown to suppress prostaglandins E2, F2a, thromboxane A2, and prostacycline; reduce capillary hyperfragility; and increase lymphatic drainage [2]. This study examines the efficacy of MPFF in preventing ovulatory menorrhagia and dysmenorrhoea due to dysfunctional uterine bleeding. In the absence of an institutional review board, the authors approved the study protocol. Consec-
Published Version
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