Abstract
The purpose of this study was to investigate the association between MCP-1 -2518G/A polymorphism and Tourette syndrome (TS) in Chinese Hanpopulation. Wecollected 324 Chinese Han individuals from 108 TS nuclear families from Chinese Hanpopulation andemployed polymerase chain reactionand restrictionenzyme digestion for determining thegenotype of MCP-1 -2518G/A polymorphism. The data were analyzed using the transmission disequilibrium test, the genotype haplotype relative risk and haplotype-based haplotype relative risk. No biases were observed in the transmission of either of the two alleles (χ2 = 0.016, df = 1, P = 0.898) to the affected probands in the total sample. The analyses of transmission disequilibrium test, haplotype relative risk and haplotype-based haplotype relative risk did not indicate any associations at MCP-1 -2518G/A with TS. Our results suggest that MCP-1 -2518G/A is not associated with susceptibility of Tourette syndrome in Chinese Han population.
Published Version
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