Abstract
Objective To investigate the association between rs1013940 in SLC5A7 and Tourette Syndrome (TS) in Chinese Han population. Methods Polymorphism was genotyped in 401 TS nuclear families trios from china by real-time fluorescent quantitive PCR. Transmission disequilibrium test (TDT) and Haplotype relative risk (HRR) were used to analyze the association between the genetic distrbution of rs1013940 and TS and the results were verified by haplotype-based haplotype relative risk(HHRR). Results No transmission disequilibrium was found between rs1013940 in SLC5A7 and TS by TDT and HRR(TDT: χ2 =0.268, P=0.657, OR=0.728, 95%CI=0.366-1.451; HRR: χ2=0.111, P=0.739, OR=0.959, 95%CI=0.762-1.466). HHRR also indicated the same result (HHRR: χ2=0.276, P=0.599, OR=1.082, 95%CI=0.806-1.453). Conclusion The result reveals that there is no significant association between rs1013940 in SLC5A7 and TS in Chinese Han population. However, the results need to be further validated in different populations. Key words: SLC5A7; Tourette syndrome; Single nucleotide polymorphism; Transmission disequilibrium test
Published Version
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