Abstract
In order to determine the effect of dietary fats on hepatic transglutaminase activity, male CD-1 mice were fed diets containing 10 wt% menhaden oil (MO) or 10 wt% corn oil (CO) for 4 weeks. Dietary fatty acids significantly altered the fatty acid composition of liver phospholipids. Arachidonic and linoleic acids were replaced by eicosapentaenoic acid and docosahexaenoic acid in mice consuming the MO diet. PGE 2 synthesis decreased by 32% in the livers from mice consuming MO compared to that observed in CO fed mice. Liver transglutaminase activity was unchanged by MO indicating that n-3 polyunsaturated fatty acids do not affect its synthesis or activity.
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