Trabecular bone score and bone mineral density in Ukrainian normal women depending on duration of postmenopausal period

Abstract

Aim: To evaluate the features of pain syndrome in knee joints, functional activity and quality of life in postmenopausal women with knee osteoarthritis (KOA) depending on parameters of bone mineral density (BMD). Materials and methods: We have examined 240 postmenopausal women aged 60–79 years with knee osteoarthritis of II–III degree, which were divided into two age groups: the 60–69 and 70–79 years old. The diagnosis of knee osteoarthritis was performed according to the criteria of ACR (1995), the stage – by Kellgren–Lawrence classification. The parameters of pain syndrome in knee joints and functional activitywere assessedby visual analogue scale, index Lequense and15-meter test; thequality of life was determined by Euro-Qol-5D. Bone mineral density was measured byDual-energy X-ray absorptiometry («Prodigy», GEMedical systems, Lunar, model 8743, 2005). To analyze the data all patients were subdivided into two groups: 1 – patients with osteoporosis and 2 – with normal BMD. Results: In patients with osteoporosis in the age group 60–69 it was found significantly higher levels of pain in the knee joints compared with women with normal BMD. Thus, the pain during upstairs walking were 7.0±2.4 and 4.8±2.6 points accordingly (F=4.27, p=0.05), pain during walking down – 8.4±0.9 and 4.9±2.9 points respectively (F=7.09, p=0.01). In patients with osteoporosis in the age group 70–79 it was found significantly lower parameters of Lequense index compared with women with normal bone tissue: 17.8±3.1 and 13.9±5.0 points respectively (F=4.96, p=0.03). All patients with KOA didnt significantly differ in data of 15-meter test and quality of life depending on the status of BMD. Conclusions: BMDparameters in postmenopausalwomen aged 60–79 years with KOA of II–III degree significantly effect the data of pain syndrome and functional activity.