Abstract
Toxicological assessment of combined fungicides proposed for application on cereal spiked crops in Ukraine was performed according approved State Sanitary Norms and Rules. Statistics, bibliographical methods were used in the study. The classes of hazard were established after evaluation of toxicometry parameters, which included assessment of acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, irritation potential to eyes (mucous membranes) and skin, and sensitizing properties. Integral hazard class of the studied formulations was established. Formulations No.1, 2, 3, 5 and 7 can be pertained to integral hazard class 2 by acute inhalation toxicity as limiting criterion of hazard (formulation No.1 also has additional point of concern – its irritation of the skin and eyes). Formulation No.4, 6 and 8 were classified as integral hazard class 3 by the same limiting criterion of hazard, but the danger of formulation No.4 possibility to cause sensitization and irritation of the eyes was taken into account. Recommendations for the studied combined fungicides application in agricultural sector of Ukraine were given. Maximum daily time of contact with formulations for workers engaged in its application on cereal spiked crops was suggested. 4 hours per day were approved for formulations No.1,2,3,5 and 7, and 6 hours per day for No. 6 and 8, respectively
Highlights
Estimation of toxic properties of active substances and TOXICOLOGICAL ASSESSMENT OF COMBINED FUNGICIDES PROPOSED FOR APPLICATION ON CEREAL SPIKED CROPS IN UKRAINEAll the studied combined pesticides were classified as hazard class 4 by acute oral toxicity pesticidal formulations on its basis is the one of the most important stages of registrationMykola Kondratiuk Postgraduate student1(except formulation No 5 – hazard class 3)
Evaluation of the formulation safety was car- tained to integral hazard class 2 by acute inhalation toxicity ried out based on the induced toxic effects in mammals, and as limiting criterion of hazard
In additional point of concern – its irritation of the skin and the course of our research, we studied fungicides on the basis eyes)
Summary
(except formulation No 5 – hazard class 3). Formulations No 1, 3, 6 were classified as hazard studies. Assessment of the safety of plant protection chemicals in. Formulations No. were classified as using the principles of the mod-. Shevchenko blvd., Kyiv, Ukraine, 01601 toxicity (4-hour exposure), and sification of pesticides [1]. The integral safety class of a specific formulation is established on the basis of hygienic and toxicometric indices as well as longterm exposure indices taking into account the limiting criteria of hazard. It is the results of toxicological studies that are the basis for the development of
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