Abstract
While injection of polyinosinic-polycytidylic acid (poly-IC) does not protect adult C3H mice against fatal brain infection with lymphocytic choriomeningitis (LCM) virus, it can have a toxic effect and bring on death four to eight hours after administration. Toxicity depends on the stage of infection of mice and on the dose of poly-IC used, and can be reduced or eliminated by administration of water and electrolytes. Administration of poly-IC gives rise to an increased induction or ⪡ priming ⪢ of interferon in relation to the level of circulating interferon induced by LCM virus. Toxicity is not, however, related to viremia. Poly-IC injected into congenitally infected mice is not toxic but does elicit a priming effect. Several hypotheses are proposed to explain this toxicity of poly-IC in mice infected with LCM virus.
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