Abstract
Commentary: Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection
Highlights
Using lymphocytic choriomeningitis virus (LCMV) clone 13 as a model of chronic viral infection in mice, investigators found that exposure to methamphetamine significantly alters the expression of peripheral T cell factors putatively involved in infection control
The expression of programmed cell death protein-1 (PD-1), type 3 inflammatory CXC chemokine receptor (CXCR3), and epidermal growth factor receptor (EGFR) was increased on T cell subsets from LCMV-infected mice exposed to methamphetamine
Given the high prevalence of chronic viral infections [e.g., human immunodeficiency virus (HIV) and hepatitis C virus (HCV)] associated with methamphetamine and other substance use disorders, including alcohol (Martínez-Raga et al, 2001), it is important to determine how substances of abuse effect T cell responses involved in the etiology and progression of chronic viral infection
Summary
The recent article by Sriram et al (2015) is one of the first studies to evaluate the effects of methamphetamine on peripheral T cell responses, in the context of a chronic viral infection. Using lymphocytic choriomeningitis virus (LCMV) clone 13 as a model of chronic viral infection in mice, investigators found that exposure to methamphetamine significantly alters the expression of peripheral T cell factors putatively involved in infection control.
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