Abstract
The objective of the present study was to determine the total content of phenolics and flavonoids in ethanol extracts of a plant from the family of Ranunculaceae – Ficaria verna. Harvesting of medicinal plant was carried out in ecologically clean regions of west Ukraine in spring 2020. The extracts were obtained by maceration of grass, leaves,and flowers to compare the content of active substances in different types of raw materials. The total phenolic content was estimated spectrophotometrically using Folin Ciocalteu method. The total flavonoid content was measured by aluminium chloride colorimetric assay. The maximum content of phenolic and flavonoids compounds was observed in the grass Ficaria verna. The antioxidant effects of the extracts were investigated. The Ficaria verna can be regarded as a promising natural plant source of antioxidant effects with a high potential for phytopreparations.
Highlights
Despite significant advances in the modeling and creation of synthetic drugs, the popularity of herbal therapy is increasing and its competence is expanding
The purpose of our study is to investigate the chemical composition of the ethanol extracts of Ficaria verna., in particular, phenolic compounds and flavonoids, and to study their and antioxidant effects
3.1 Total phenolic and flavonoid contents The total content of phenolic compounds in the investigated extracts was determined, the result is expressed in mg of gallic acid per g of plant material
Summary
Despite significant advances in the modeling and creation of synthetic drugs, the popularity of herbal therapy is increasing and its competence is expanding. The world pharmaceutical industry is making extensive use of herbal raw materials, which are the basis for the creation of medicines. A large number of drugs that are manufactured worldwide have natural ingredients of plant origin. Undesirable side effects of drugs, including those of synthetic origin, are observed in 10-40% of patients and are one of the obstacles in the development of new drugs. The percentage of side effects significantly increases during self-medication. In more than 60% of cases of self-medication, there was observed irrational and unjustified use of drugs. It is promising to expand the range of herbal medical products with new effective plant-based preparations, in particular those based on the herbs widely used in ethnomedicine
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