Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients.

Dagmar Horáková,Dalibor Novotný,Vladimír Janout,Milada Hobzová,Dana Galuszková,Kateřina Azeem,Sandra Doněvská,Jana Vrbková,Arnošt Martínek,Vladimír Horák,Helena Kollárová,Dalibor Pastucha,Lenka Dumbrovská,Radka Benešová,Zdeněk Švagera

doi:10.1155/2015/545068

Abstract

The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.

Highlights

Adiponectin, a protein produced by adipocytes, plays an important role in the metabolism of glucose and lipids
The mean total adiponectin level was high at 10.6 mg/L (10.34 mg/L in females and 8.04 mg/L in males)
The mean total adiponectin and mean high molecular weight (HMW) adiponectin levels were higher in females compared to males

Summary

Introduction

Adiponectin, a protein produced by adipocytes, plays an important role in the metabolism of glucose and lipids. Adiponectin circulates in human serum as high molecular weight (HMW form) and low molecular weight (LMW form) oligomers. The ratio of the HMW form to the total adiponectin level is referred to as the adiponectin sensitivity index [1]. Experimental in vitro animal studies have shown that adiponectin affects many pathways potentially leading to coronary heart disease (CHD). Adiponectin protects the vascular endothelium and has anti-inflammatory effects [2]

Methods

Results

Conclusion