Abstract
ObjectiveTo determine whether baseline levels or intervention-associated changes in total and high molecular weight (HMW) adiponectin levels were associated with insulin resistance after six months of behavioral treatment for weight loss.DesignAn ancillary study to a behavioral weight loss trial; the intervention was delivered in group sessions.MethodsParticipants included 143 overweight/obese adults with a mean BMI of 33.7 kg/m2. The sample was 88% female, 67% white, and 44.2 ± 8.5 years old. Circulating adiponectin levels (total and HMW) and the homeostasis model assessment (HOMA) of insulin resistance were measured and evaluated.ResultsAt baseline, there was significant inverse associations between total adiponectin and HOMA (p < 0.001) and between HMW adiponectin and HOMA (p < 0.001) independent of weight. At 6-mo, there was a 17% improvement in HOMA, 8% increase in total adiponectin, 17% increase in HMW adiponectin levels, and 8.72% weight loss (p’s for all< 0.001). There was also a significant inverse association between changes in total adiponectin and HOMA (p = 0.04) that was independent of baseline weight and weight loss. In contrast, the association between changes in HMW adiponectin and HOMA was attenuated after adjustment for weight loss.ConclusionsAn increased level of total adiponectin was associated with improved insulin sensitivity, regardless of baseline weight and weight loss. However, baseline total and HMW adiponectin levels were more strongly associated with HOMA than changes in these measures at six months. HMW adiponectin level was not related more closely to insulin resistance than total adiponectin level.
Highlights
MethodsStudy designThis was an ancillary study to the PREFER trial, an 18-month behavioral weight loss study designed to evaluate the effects of treatment preference (Preference-Yes vs. Preference-No) and two dietary treatment options, standard calorie restricted low fat diet (STD-D) vs. lacto-ovo-vegetarian diet (LOV-D)
There were no significant differences in total adiponectin level by diet group (7.82 ± 3.74 vs. 7.64 ± 2.87 ug/ml; p = 0.7) or preference group (7.76 ± 3.57 vs. 7.62 ± 7.66 ug/ml; p = 0.7), nor did high molecular weight (HMW) adiponectin level differ by diet group (3.33 ± 2.21 vs. 3.23 ± 1.68 ug/ml; p = 0.8) or preference group (3.30 ± 1.97 vs. 3.23 ± 20.01; p = 0.8)
An increased level of total adiponectin contributed to improved insulin sensitivity regardless of baseline weight and weight loss
Summary
Study designThis was an ancillary study to the PREFER trial, an 18-month behavioral weight loss study designed to evaluate the effects of treatment preference (Preference-Yes vs. Preference-No) and two dietary treatment options, standard calorie restricted low fat diet (STD-D) vs. lacto-ovo-vegetarian diet (LOV-D). This was an ancillary study to the PREFER trial, an 18-month behavioral weight loss study designed to evaluate the effects of treatment preference (Preference-Yes vs Preference-No) and two dietary treatment options, standard calorie restricted low fat diet (STD-D) vs lacto-ovo-vegetarian diet (LOV-D). Participants were randomly assigned first to one of the two preference conditions (yes or no). If assigned to the Preference-No condition, they were further randomly assigned to one of the two diet conditions, STD-D or. If assigned to Preference-Yes condition, they were assigned to the diet they indicated as preferred at screening. The design, recruitment, and randomization procedures for the PREFER trial have been described in detail elsewhere.[20] Refer to Figure 2 for the number of participants at each stage. The current analysis was limited to the 143 participants whose sera samples were available from baseline and 6-month assessments
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