Abstract
Porokeratotic Eccrine Ostial and Dermal Duct Nevus (PEODDN) is a rare disorder of keratinization characterized by the presence of cornoid lamellae and association with eccrine sweat ducts. These lesions are usually benign and asymptomatic, so treatment is often for cosmetic purposes. Current therapies for PEODDN are either insufficient or impractical. We present a case of PEODDN treated with topical tretinoin 0.05% cream and 5-fluorouracil 5% cream with the hopes of providing an efficacious, financially relevant, and well-tolerated treatment regime for PEODDN. The combination of topical tretinoin and 5-fluorouracil did not provide substantial improvement in the lesions of a patient treated with this therapy for 6 weeks, and further studies are needed to identify an efficacious treatment for PEODDN that is both well-tolerated and economically feasible for patients with this condition.
Highlights
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare disorder of keratinization that was first named by Abell and Read in 1980 [1]
We report a case of PEODDN treated with a six week combination of tretinoin 0.05% cream and 5-fluorouracil 5% cream daily, which did not show improvement in this lesion
The reported blaschkoid distribution of PEODDN suggests a genetic abnormality with possible somatic mosaicism occurring during embryogenesis [7], but interestingly, only one case of familial PEODDN has been reported, suggesting a complex mode of
Summary
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare disorder of keratinization that was first named by Abell and Read in 1980 [1]. PEODDN usually presents at birth as comedo-like punctate pits that usually affect the hands and feet but can be widespread and follow Blaschko lines [2]. PEODDN may become more verrucous appearing with time, and lesions are usually asymptomatic mild pruritus has been reported [2].
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