Abstract
The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes as related to the pathogenesis of atopic dermatitis (AD). This disorder results in inflammation of the skin characterized by itchiness, red skin, a rash, by the accumulations of large numbers of Staphylococcus aureus their toxins and proinflammatory agents secreted by migrating neutrophiles are considered the main cause of AD pathogenicity.
Highlights
The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes as related to the pathogenesis of atopic dermatitis (AD) [1,2]. This disorder results in inflammation of the skin characterized by itchiness, red skin, a rash, by the accumulations of large numbers of Staphylococcus aureus their toxins [2] and proinflammatory agents secreted by migrating neutrophiles [3], are considered the main cause of AD pathogenicity
The major damage induced to skin cells, The idea that a mechanism of autoimmunity could play a role in the pathogenesis of atopic dermatitis is based on the observation that patients with atopic dermatitis display IgE reactivity to a variety of human protein antigens
A broad spectrum of at least 140 IgE-binding self-antigens associated with atopic dermatitis has been demonstrated which might promote, and perpetuate, skin inflammation by binding IgE antibodies or activating may be due to migrating PMNs and their released toxic agents
Summary
Staphylococci, migrating neutrophils which accumulate in large numbers can undergo netosis [5,6]. The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes as related to the pathogenesis of atopic dermatitis (AD) [1,2] This disorder results in inflammation of the skin characterized by itchiness, red skin, a rash, by the accumulations of large numbers of Staphylococcus aureus their toxins [2] and proinflammatory agents secreted by migrating neutrophiles [3], are considered the main cause of AD pathogenicity. By binding by strong electrostatic forces to negatively-charged domains in immune complexes, complement components and upon staphylococcal cells, these highlycharge cationic polyelectrolytes may facilitate the deposition and internalization of immune complexes and staphylococci by professional phagocytes such as neutrophils and macrophages
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