Abstract
Egg albumin microspheres containing vitamin A (15.7 ± 0.8% w/w; size 222 ± 25 μm) were produced by an emulsion method. These particles were used to prepare O/W creams of vitamin A. The in vitro and in vivo drug release of a microencapsulated vitamin A cream was studied and compared with a non-microencapsulated vitamin A cream. The in vivo study in six volunteers shows that these microspheres were able to remain on the skin for a long period of time, and as a consequence they were able to prolong the release of vitamin A. The relative availability of the microencapsulated vitamin A cream, compared with the non-microencapsulated vitamin A cream was 78.2 ± 7.3%.
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