To study the surface modified cobalt zinc ferrite nanoparticles for application to magnetic hyperthermia

Suman Halder,S S Sikder,S Manjura Hoque,A Nahar,S I Liba

doi:10.1063/5.0029135

Abstract

In the present work, we have studied the influence of the annealing temperature and concentration of Co0.5Zn0.5Fe2O4 nanoparticles as a heat generation material for hyperthermia therapy. Cobalt zinc ferrite (Co0.5Zn0.5Fe2O4) nanoparticles were synthesized by the chemical co-perception method and annealed at 200 °C, 400 °C, and 600 °C for 3 h. The structural characterization was carried out using an x-ray diffractometer, and all samples exhibit a single-phase spinel structure. The M-H loop of the as-dried and annealed samples revealed a narrow “S” shaped hysteresis cycle, which exhibits the superparamagnetic behavior of all samples. The Mössbauer spectrum of all samples at room temperature showed a doublet, which is the signature of the superparamagnetic nature, and it is in good agreement with the acquired M-H curves. Surface modifications of the as-dried and annealed nanoparticles were achieved by coating the nanoparticles with chitosan, and solutions of different concentrations (1 mg/ml, 2 mg/ml, 4 mg/ml, and 6 mg/ml) were prepared. Employing dynamic light scattering measurement, the hydrodynamic diameter of the chitosan-coated nanoparticles at 37 °C was found to be between 173 nm and 231 nm, and the polydispersity index was less than 0.30 for all concentrations. The induction heating measurements indicated that the heating efficiency of chitosan-coated nanoparticles increased according to the order of annealing temperature (600 °C &gt; 400 °C &gt; 200 °C&gt; as-dried) and the solution of concentration (6 mg/ml &gt; 4 mg/ml &gt; 2 mg/ml &gt; 1 mg/ml).

Highlights

The use of magnetic nanoparticles in cancer therapy is one of the most exciting advancements of nanotechnology in the healthcare sector
Co0.5Zn0.5Fe2O4 nanoparticles have been successfully synthesized by chemical co-precipitation routes and annealed at three different temperatures
Through x-ray diffractometer (XRD) analysis, it is found that all samples are of a single-phase cubic spinel structure and the growth of the grain is observed at higher annealing temperature

Summary

Introduction

The use of magnetic nanoparticles in cancer therapy is one of the most exciting advancements of nanotechnology in the healthcare sector. Single-domain magnetic nanoparticles with appropriate size and properties can be applied to magnetic fluid hyperthermia in cancer therapy. In this technique, magnetic nanoparticles first have to be brought to the target infected area, where they can be heated up by an AC magnetic field of proper strength and frequency. During the magnetic hyperthermia therapy, magnetic nanoparticles dissipate applied magnetic energy into heat mainly via a relaxation loss process, and this heat generation strongly depends on the chemical composition, particle size, size distribution, anisotropy constant, saturation magnetization, and surface modification.. Application in hyperthermia therapy and other in vivo biomedical applications requires the magnetic particle to be less toxic and stable in a physiological environment During the magnetic hyperthermia therapy, magnetic nanoparticles dissipate applied magnetic energy into heat mainly via a relaxation loss process, and this heat generation strongly depends on the chemical composition, particle size, size distribution, anisotropy constant, saturation magnetization, and surface modification. For hyperthermia therapy, the application of nanoparticles that possess superparamagnetic behavior at room temperature is preferred. application in hyperthermia therapy and other in vivo biomedical applications requires the magnetic particle to be less toxic and stable in a physiological environment

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Conclusion