To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology.

Yang-fan Li,Siba shanak,Yi-tao Xue,Yi-ping Xiu,Yi-ding Yu

doi:10.1155/2020/8852877

Abstract

Fuxin mixture (FXHJ) is a prescription for the treatment of heart failure. It has been shown to be effective in clinical trials, but its active ingredients and mechanism of action are not completely clear, which limits its clinical application and international promotion. In this study, we used network pharmacology to find, conclude, and summarize the mechanism of FXHJ in the treatment of heart failure. From FXHJ, we found 39 active ingredients and 47 action targets. Next, we constructed the action network and was conducted enrichment analysis. The results showed that FXHJ mainly treated heart failure by regulating the MAPK signaling pathway, PI3KAkt signaling pathway, cAMP signaling pathway, TNF signaling pathway, toll-like receptor signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and the apoptotic signaling molecule BCL2. Through the research method of network pharmacology, this study summarized the preliminary experiments of the research group and revealed the probable mechanism of FXHJ in the treatment of heart failure to a certain extent, which provided some ideas for the development of new drugs.

Highlights

Heart failure (HF) is a closed result of most cardiovascular diseases, which may be caused by damage to ventricular filling from various structural or functional disorders of the heart [1]
In the treatment of heart failure, how to slow or even reverse ventricular remodeling has grown up to be a hot topic in recent years
We have studied the relevant pathways, including the MAPK signaling pathway, the PI3KAkt signaling pathway, the cAMP signaling pathway, the TNF signaling pathway, and the apoptotic conduction molecule BCL2

Summary

Introduction

Heart failure (HF) is a closed result of most cardiovascular diseases, which may be caused by damage to ventricular filling from various structural or functional disorders of the heart [1]. FXHJ is a prescription for the treatment of heart failure obtained by Dr Xue through the combination of clinical experience and literature data. It is composed of Aconiti Lateralis Radix Praeparata (FZ), Angelicae Sinensis Radix (DG), Phellodendri Chinrnsis Cortex (HB), Lepidii Semen Descurainiae Semen (TLZ), Epimrdii Herba (YYH), and Alisma Orientale (ZX). Preliminary clinical trials of the research group have shown that FXHJ can significantly improve cardiac function, delay left ventricular remodeling, extend the 6WMT distance, improve exercise tolerance, reduce plasma BNP level, and improve patients’ quality of life [3]

Methods

Results

Conclusion