Abstract
Radix Astragali and Semen Lepidii (HQ-TLZ) is a commonly used herbal medicine combination for treatment of heart failure, which has a good clinical effect. However, its active components and mechanism of action are not clear, which limits its clinical application and development. In this study, we explored the mechanism of action of HQ-TLZ in the treatment of heart failure based on network pharmacology. We obtained 11 active ingredients and 109 targets from the TCMSP database and SwissTargetPrediction database. Next, we constructed the action network and carried out enrichment analysis. The results showed that HQ-TLZ treatment of heart failure is primarily achieved by regulating the insulin resistance, erbB signaling pathway, PI3K-Akt signaling pathway, and VEGF signaling pathway. After inverse targeting, molecular docking, and literature search, we determined that the equivalent molecular groups of HQ-TLZ in the treatment of heart failure were quercetin and kaempferol. Based on network pharmacology, we reveal the mechanism of action of HQ-TLZ in the treatment of heart failure to a certain extent. At the same time, we determined the composition of the equivalent molecular group. This provides a bridge for the consistency evaluation of natural herbs and molecular compounds, which is beneficial to the development of novel drugs and further research.
Highlights
Heart failure (HF), the ultimate cause of most cardiovascular diseases, is the result of the filling or ejection of damaged ventricles caused by various cardiac structural or functional disorders [1]
Cardiac remodeling runs through the occurrence and development of heart failure and is one of the main factors determining cardiac function and prognosis
Network pharmacology is a combination of bioinformatics, multimodal pharmacology, network data analysis, and computer technology to explore the association between drugs and diseases through the analysis of the “drug-targets-disease” interaction network [4]. erefore, this study aims to analyze the mechanism of action of HQ-TLZ in the treatment of heart failure through the network pharmacology method and find the equivalent molecular groups of these two traditional Chinese herbals
Summary
Heart failure (HF), the ultimate cause of most cardiovascular diseases, is the result of the filling or ejection of damaged ventricles caused by various cardiac structural or functional disorders [1]. Cardiac remodeling runs through the occurrence and development of heart failure and is one of the main factors determining cardiac function and prognosis. HQTLZ is a commonly used and efficacious herbal combination for the treatment of heart failure [3], but its active components and mechanism of action are still unclear. Erefore, this study aims to analyze the mechanism of action of HQ-TLZ in the treatment of heart failure through the network pharmacology method and find the equivalent molecular groups of these two traditional Chinese herbals Network pharmacology is a combination of bioinformatics, multimodal pharmacology, network data analysis, and computer technology to explore the association between drugs and diseases through the analysis of the “drug-targets-disease” interaction network [4]. erefore, this study aims to analyze the mechanism of action of HQ-TLZ in the treatment of heart failure through the network pharmacology method and find the equivalent molecular groups of these two traditional Chinese herbals
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