Abstract

It is well known that the loss of more than 40 % of the skin surface due to a burn is life-threatening and is accompanied by a shortage of skin suitable for transplantation. The physiological temporary replacement of the skin and saving the patient's skin during the final closure of wounds are crucial in the strategy of helping such victims. These goals can be achieved by using biological analogues of the lost skin: allogeneic cadaveric skin or tissue equivalents (materials containing skin cells). Currently, there is no production of available tissue equivalents with viable cells in the Russian Federation for the treatment of burn wounds, while the worldwide practice has accumulated significant experience in their use, and their strengths and disadvantages have been analyzed. The review presents literature data on terminology and classifications of tissue equivalents, taking into account the possibilities of their practical application, and their current clinical significance. The article describes the results of a limited clinical application of the biological equivalent of the skin developed by the N. K. Koltsov Institute of Developmental Biology of the RAS for patients with burns.

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