Abstract
Background: Thyroid hormones are known to have effects on multiple systems, including the cardiovascular system. Hypothyroidism leads to hypercholesterolemia, hyperfibrinogenemia, hyperhomocysteinemia, platelet abnormalities, and systemic vasculitis, all of which can adversely affect the cardiovascular system. Objectives: The objective of this study was to evaluate the lipid abnormalities and thyroid function in cases suffering from coronary artery disease (CAD). Material and Methods: A case-control study was conducted involving 100 patients admitted to the Department of Cardiology in N.R.S Medical College, Kolkata, with CAD as the case and 100 age-matched healthy individuals as controls. Patients with post-percutaneous transluminal coronary angioplasty and post-coronary artery bypass graft were not included in the study. Patients taking amiodarone, lithium, or iodine-containing drugs and giving a history of thyroid disorder, renal disorder, or liver cirrhosis were excluded from the study. Blood glucose and thyroid hormones were estimated as per standard procedure. Results: Fasting plasma glucose, hemoglobin A1C, serum total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free triiodothyronine levels, and high-density lipoprotein cholesterol were found to be significantly higher and lower, respectively, among cases. Conclusion: Sick euthyroid syndrome with low T3 has been reported as an important marker for the severity of CAD and has been reported to predict mortality in cardiac care unit (CCU) patients. Inclusion of thyroid profile during assessment of risk factors of CAD may be recommended.
Published Version
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