Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes as antimicrobial agents

Abstract

Metal complexes of Schiff base ligands (exhibit imine -C = N- functional group) derived from thiosemicarbazide and 1,3,4 thiadiazole have attracted the attention of researchers on account of excellent broad range applications in a variety of fields from material sciences to biological sciences. Broad range of factors such that involvement of N, S, and O donor atoms, chelating property, chemical adaptability, minimum toxicity owing to -N-C = S linkage, structure topologies and diversity, polydentate ligands, aromaticity, extended conjugations in 1,3,4 thiadiazole and stability accommodate pharmacological potential. Widespread organic precursors (aromatic aldehyde and primary amine) have been used for the development of novel Schiff base ligands and metal complexes. Metal chelates inclusive of d-block transition metals and non-transition metals with broad distinct features have also been synthesized and evaluated via various classical and advanced spectral and analytical techniques. This review encompasses the synthesis, spectral studies and investigations that have been reported for Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes followed by evaluation of wide variety of biological applications. This review summarizes advancements in research over the last 15 years (2007–2022).