Abstract
New hydrazone Schiff base ligands were synthesized from the condensation of cinnamaldehyde and three different hydrazides (benzhydrazide, isoniazid, and 4-phenylsemicarbazide), and these compounds were further reacted with copper(II) ion affording three different Schiff base metal complexes. All hydrazone Schiff base ligands and their respective metal complexes were chemically characterised using NMR, FTIR, CHN analyses, and UV-visible spectrophotometry and these chemical analyses showed successful coordination of hydrazone Schiff base ligands to copper(II) ion. All synthesized Schiff base ligands and metal complexes were screened against Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, and Pseudomonas aeruginosa. Interestingly, all Schiff base metal complexes showed a higher antibacterial activity than their parent hydrazone Schiff base ligands; as shown by an increase of up to 60% of inhibition observed for one of the metal complexes.
Highlights
The infection of microorganism has caused massive economic losses and threats to the human population [1]
The zone of inhibition for Schiff base metal complexes for both copper(II) and nickel(II) showed a stronger antibacterial activity compared to antibiotics as the zone of inhibition range for Schiff base metal complexes is much larger as opposed to when antibiotics were used
General features of Schiff base ligands, L1–L3 Hydrazone Schiff bases L1, L2, and L3 were synthesized through the condensation reaction of cinnamaldehyde with three different types of hydrazides, benzhydrazide, isoniazid, and 4-phenylsemicarbazide, in a relatively good yield
Summary
The infection of microorganism has caused massive economic losses and threats to the human population [1]. Due to the fastgrowing rate of bacteria that are resistant against available antibiotic drugs, the development of a new and effective antibacterial drug is vital, as cure or therapies to common infections would be problematic in future if the issue is not resolved [2]. Schiff base metal complexes involving the transition metals in the first row, namely cobalt(II), copper(II), and nickel(II), were widely studied and their importance in improving selected pharmaceutical activities is evident [9, 10, 11]. Most of the transition metal complexes involving Schiff base ligands have proven to exhibit strong biological potencies notably in antibacterial, anti-inflammatory, antifungal, antiviral, antimalarial, antiproliferative, antitubercular, and antipyretic properties [6, 12, 13, 14, 15]. The zone of inhibition for Schiff base metal complexes for both copper(II) and nickel(II) showed a stronger antibacterial activity compared to antibiotics as the zone of inhibition range for Schiff base metal complexes is much larger as opposed to when antibiotics were used
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
