Abstract
Natural products have long been and continue to be attractive source of nutritional and pharmacological therapeutics. Interest in natural compounds as potential therapies for metabolic syndrome have recently focused on hydroxylated aromatics, such as resveratrol. Another compound of interest in this regard is mangiferin, the predominant constituent of extracts of the mango plant Mangifera indica. Mangiferin has documented antioxidant, cardioprotective and anti-inflammatory effects. Recently, pilot studies indicate bioactivity of this compound in mediating insulin sensitivity and modulating lipid metabolism. In this review we provide information on what we know about the impact of mangiferin on important biological processes involved in metabolic disorders.
Highlights
Metabolic syndrome is a combination of medical conditions including obesity, diabetes, nonalcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD) and kidney dysfunctions
Metabolic syndrome involves interplay among several organs such as liver, muscle, heart, adipose tissues and pancreas, many types of cells, numerous genes and proteins, and multiple metabolic processes including gluconeogenesis, glycolysis, lipogenesis and lipolysis, all of which are regulated by complex networks and influenced by many factors such as hormones
More comprehensive studies of the mechanisms of action of MGF are needed to better understand these phenomena, these preliminary reports suggest that MGF suppresses lipogenesis and stimulates lipolysis, thereby preventing high fat diet (HFD) induced metabolic syndrome
Summary
Metabolic syndrome is a combination of medical conditions including obesity, diabetes, nonalcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD) and kidney dysfunctions. Metabolic syndrome involves interplay among several organs such as liver, muscle, heart, adipose tissues and pancreas, many types of cells, numerous genes and proteins, and multiple metabolic processes including gluconeogenesis, glycolysis, lipogenesis and lipolysis, all of which are regulated by complex networks and influenced by many factors such as hormones. Treating and preventing metabolic disorders require modulation of a variety of genes, proteins, cellular signaling pathways and biological processes.
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