Abstract
Background: Low-molecular components of colostrum (LMWCC) have a pronounced biological activity. We investigated the effect of different doses of LMWCC (0.01, 0.1, 1 and 5 g/100 g of body weight) on the behavior, dynamics of growth, acute and chronic toxicity, as well as the relative weight of the liver, spleen and kidneys of the experimental animals. Methods: We used 100 3-month male rats in the experiment. All animals were divided into 5 groups of 20 animals in each group, LMWCC was administered per os, and the control group received sterile water. Results: LMWCC revealed no pirogenic effect in a wide diapason of doses (0,01-5 g/100 g of animal mass). Immediately after the LMWCC administration the short-time decrease in the motion activity was observed. The low doses of LMWCC induced diarrhea in 10-20 % of of animals, the super-large dose – in 75% of animals. The acute toxicity of LMWCC (death of 15 % of animals) was detected only in super-large dose of LMWCC and it was accompanied by pronounced diarrhea. LMWCC influenced the mass of liver, spleen and kidney. 60 days after LMWCC administration the mass of liver was restored to control weight, but the mass of spleen and kidney was not restored. Conclusion: LMWCCdo not have chronic toxicity and can be attributed to non-toxic compounds with a possible side effect - a violation of the digestive system.
Highlights
Colostrum is a unique biologically active product that is formed in the mammary gland of mammals in the first few days after the beginning of lactation [1, 2].It can be assumed that reproduction of colostrum is an important evolutionary "acquisition", what promotes the resistance of newly born mammals to aggressive action of environmental factors
It is known that a large number of biologically active compounds enter into the composition of colostrum that affects the functions of the immune system [5, 6]; it removes inflammatory reactions [7,8,9]; it is used even in the treatment of a number of serious pathologies [1012]
In this work we investigated the effect of different doses of LMWCC: from small (0.01 g/100 g of body weight), potentially therapeutic (0.1 g/100 g of body weight), large (1 g/100 g of body weight) and "superlarge" (5 g/100 g of body weight), on the behavior and general condition, as well as the manifestation of toxicity in experimental animals)
Summary
Colostrum is a unique biologically active product that is formed in the mammary gland of mammals in the first few days (up to 5 days) after the beginning of lactation [1, 2]. It can be assumed that reproduction of colostrum is an important evolutionary "acquisition", what promotes the resistance of newly born mammals to aggressive action of environmental factors. At early stages of the postnatal development, the epigenetic memory and metabolic memory are formed and remained throughout the ontogenesis, and the colostrum components may influence their formation [3, 4]. A transfer factor has been isolated from the colostrum, which shows an expressed biological activity [13, 14]. Low-molecular components of colostrum (LMWCC) have a pronounced biological activity. We investigated the effect of different doses of LMWCC (0.01, 0.1, 1 and 5 g/100 g of body weight) on the behavior, dynamics of growth, acute and chronic toxicity, as well as the relative weight of the liver, spleen and kidneys of the experimental animals
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