Abstract
This study aimed to determine whether I/D polymorphism predispose to the development of MI in Tunisia. 50 patients with coronary artery disease complicated by MI and 70 healthy controls were analyzed. Quantitative analyses lipids are founded. DNA was isolated from blood samples. Polymorphisms were assessed by polymerase chain reaction method. Statistical differences between groups were determined by Chi-square test. Compared to controls, cases have significantly higher levels of total cholesterol, triglycerides and LDL-cholesterol and lower level of HDL-cholesterol. There are no significant differences between patients and controls in terms of allelic and genotypic frequencies. However, the frequency of the “I” allele is higher in cases which have 2 MI (p=0.0354). Additionally, a statistically significant association between diabetes, arterial high blood pressure, family history and cigarette smoking with MI was founded (p<0.01). I/D polymorphism of t-PA gene is not associated with MI in this sample of Tunisian population.
Highlights
Hematopoietic growth factors involved granulocyte-colony stimulating Factor (G-CSF) and erythropoietin (EPO) are cytokines involved in the regulation of normal hematopoiesis, influence stem cells survival, proliferation, and differentiation commitment [1,2]
CO intoxication, a common cause of death especially during winter, induces cerebral hypoxia-ischaemia. It triggers neuropathological events include neutrophil degradation, enhancement and activation of myeloperoxidase, oxidative stress and lipid peroxidation, inflammation, apoptosis, demyelination and necrosis which may result in delayed neurological sequel [17,18]
A single dose of G-CSF and EPO could attenuate CO neurotoxicity, alleviated histological changes such as neutrophil infiltration and neural necrosis which was shown by H&E staining
Summary
Therapeutic Potential of Hematopoietic Growth Factors for Treatment of Carbon Monoxide Neurotoxicity Maryam Ghorbani1, Seyed Adel Moallem2, Amir Hooshang Mohamadpour2 and Shabnam Shahsavand3* 1Department of Pharmacology and Toxicology, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran 2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 3Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Hematopoietic growth factors involved granulocyte-colony stimulating Factor (G-CSF) and erythropoietin (EPO) are cytokines involved in the regulation of normal hematopoiesis, influence stem cells survival, proliferation, and differentiation commitment [1,2].
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