Abstract
The quaternary salts of the styryl quinolines (Browning, Cohen, Ellingworth and Gulbransen, 1926, 1929) which possess active trypanocidal properties in vivo , can usually be prepared in two ways—( a ) by condensation in presence of piperidine of the quaternary salt of the quinaldine derivative with the aldehyde (method I), or ( b ) by forming the quaternary salt by the addition of methyl sulphate or alkyl halide subsequent to condensation with the aldehyde, using zinc chloride as condensing agent (method II). It was found that certain compounds synthesised by method II were strikingly deficient in trypanocidal action as compared with their isomerides prepared by method I ; there were also marked differences in chemical and physical properties. The present investigation elucidates these differences.
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Schedule a callMore From: Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
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