Therapeutic effect of hyperbaric oxygen therapy on patients with severe craniocerebral injury and its influence on serum interleukin-1 beta and interleukin-6 levels

Abstract

Objective To explore the clinical curative effect of hyperbaric oxygen therapy for severe craniocerebral injury, and its influence on the level of serum interleukin-1 beta(IL-1 ) and interleukin-6(IL-6). Methods 150 patients with severe craniocerebral injury were selected and divided into two groups by random and single blind method.75 patients of the control group were treated with conventional therapy, 75 patients of the observation group were given hyperbaric oxygen on the basis of the conventional treatment, and the clinical efficacy was compared between the two groups. Results The total effective rate of the observation group was 94.67%, which was significantly higher than 77.33% of the control group, the difference was statistically significant(χ2=7.83, P 0.05). After treatment, the GCS and ADL scores of the observation group were (12.18±2.13)points, (67.46±12.55)points, which were significantly higher than those before treatment(t=8.01, 7.76, all P 0.05). After treatment, the serum levels of IL-1 and IL-6 in the observation group were (127.48±16.35)pg/mL, (89.66±13.47)pg/mL, which were significantly lower than before treatment(t=8.34, 7.89, all P<0.05), there were significant differences between the two groups(t=7.65, 7.22, all P<0.05). Conclusion Implementation of hyperbaric oxygen in patients with severe traumatic brain injury on the basis of conventional symptomatic treatment can effectively improve the clinical symptoms and signs, reduce the serum IL-1 and IL-6 levels, promote the recovery of brain function and ability of daily life, and which is worth to be promoted in clinical. Key words: Craniocerebral trauma; Hyperbaric oxygenation; Interleukin-1 beta; Interleukin-6