Therapeutic effect of Azithromycin in the combine-sequential therapy for infants with wheezing

Abstract

Objective Early studies had confirmed that the combine-sequential therapy in the treatment of acute attacks of wheezing infants was safe and effective, this study aims to further explore the role of oral azithromycin in the combine-sequential therapy. Methods According to the principles of randomized, 56 wheezing infants were divided into Azithromycin group and control group from Aug.2012 to Apr.2013, and there were 29 children in the Azithromycin group and 27 children in the control group.The treatment protocol of Azithromycin group were oral Azithromycin 10 mg/(kg·d), 3 days; oral prednisone 5 mg/d, 3 days; Tulobuterol Patch 0.5 mg/d, 7 days; oral Ioratadine 3 mL/d, 7 days; oral Montelukast 4 mg/d, 7 days.Control group was without Azithromycin, and the rest of drugs were the same as Azithromycin group.The symptom scores of coughing, wheezing, wheezing sound and the difficulty of expectoration in the 1st day, the 3rd day, and the 7th day were recorded. Results 1.The Azithromycin group and the control group could both improve the children's symptom scores of coughing, wheezing, wheezing sound and the difficulty of expectoration, the 2 groups of children before and after treatment of the symptom scores differences were statistically significant (5.41±1.40, 4.85±1.13 vs 1.14±0.78, 2.93±1.00)(S=217.5, 147.0, all P<0.05).2.The Azithromycin group had more improvement at the symptom scores of coughing, wheezing, wheezing sound and the difficulty of expectoration than those of the control group in the third day (0.52±0.51, 0.28±0.45, 0.24±0.44, 0.38±0.49 vs 0.89±0.42, 0.74±0.45, 0.62±0.69, 0.67±0.48)and the 7th day (0.24±0.44, 0.21±0.41, 0.07±0.26, 0.21±0.41 vs 0.52±0.51, 0.48±0.51, 0.37±0.49, 0.48±0.51), and the symptom score differences were statistically significant(Z=2.75, 3.44, 2.90, 2.12, 2.11, 2.13, 2.71, 2.13, all P<0.05). Conclusions Azithromycin + Tulobuterol patch + Prednisone + Loratadine + Montelukast combination consisting of sequential therapy can improve children with acute wheezing cough, wheezing, wheezing, difficulty of the expectoration symptoms, azithromycin is an effective component of infants wheezing combined sequential treatment regimen. Key words: Azithromycin; Wheezing; Combine; Sequential; Infant